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    FIGURE 3. 4D image of a dividing cell that was detected by Aivia in a feedback loop with LAS X from Leica Microsystems.
    (Courtesy of Gowerlabs)
    FIGURE 1. The researchers use LUMO, a wearable, portable, high-density functional NIR imaging device equipped with modular tiles with built-in NIR light sources and detectors.
    (Image credit: Lingjie Kong)
    FIGURE 1. Schematic of neurochemical sensing in vivo with FOPECs.
    (Courtesy of J. Chen et al., Nat. Methods; doi:10.1038/s41592-023-01820-3)
    FIGURE 1. An optomechanical design of the SMURF two-photon microscope.
    (Courtesy of Anna Maria Reuss, Fabian Voigt)
    Detailed image of neurons in a mouse brain, as captured using the Schmidt objectives.
    (Courtesy of Ian Shih, UNC School of Medicine)
    FIGURE 1. The experimental fMRI-fiber photometry platform could offer a deeper understanding of the dynamic properties of brain states and their relationship to behaviors.

    Highlights

    (Courtesy of Salk Institute)
    Salk researchers developed two wearable microscopes to image cellular activity in previously inaccessible regions of the spinal cord of moving mice in real time.
    Bio&Life Sciences

    Wearable microscopes help image cellular activity in spinal cords of on-the-move mice

    Justine Murphy
    April 5, 2023
    Two tiny wearable microscopes for mice are generating high-resolution, high-contrast, multicolor images in real time—providing insight into signaling patterns within spinal cords...
    (Courtesy of Osaka Metropolitan University)
    A new system allows researchers to control a nematode worm with light-sensitive proteins (opsins) triggered by white, UV, and green.
    Bio&Life Sciences

    Controlling nematode behavior with light

    Justine Murphy
    Jan. 18, 2023
    A new optogenetics-based system using various wavelengths of light is poised to significantly accelerate bio-related research.
    (Courtesy of Abraham Beyene, Howard Hughes Medical Institute Janelia Research Campus)
    A schematic of DopaFilm shows spatially resolved hotspots of activity (top) and DopaFilm’s fluorescent nanosensors glow brighter when exposed to dopamine (bottom).
    Bio&Life Sciences

    Material made of fluorescent nanosensors may boost neural discoveries

    Justine Murphy
    Oct. 26, 2022
    By measuring the release of dopamine and other neurotransmitters, a composite material can help provide a better understanding of chemical neurotransmission.
    (Courtesy of L. Fu et al.)
    FIGURE 1. The construction of a multichannel fiber photometry system. A light beam from a 488 nm laser is coupled into all multimode fibers simultaneously by an objective. The emitted fluorescence is then collected by the same optical fibers and detected by a sCMOS camera (a). The fiber end faces on the sCMOS camera for the dual-channel mode (b) and four-channel mode (c).
    Bio&Life Sciences

    Advances in fiber photometry help demystify the brain

    Justine Murphy
    Aug. 9, 2022
    Increasingly preferred over conventional brain imaging techniques, optical fiber photometry is allowing a better a grasp of the brain’s innerworkings. But this is only the beginning...
    FIGURE 1. Three-photon excitation uses 3x the wavelength as conventional one-photon absorption. The 1300 nm excitation scheme shown here is for GCaMP6s, a genetically expressed calcium indicator. Recently Chris Xu and colleagues have demonstrated that 1300 nm can also excite longer-wavelength dyes such as Texas Red, a fluorescent dye that can be bonded to antibodies to label specific cellular components.
    Bio&Life Sciences

    Laser developments support advanced neuroscience techniques

    Marco Arrigoni
    June 21, 2022
    Three-photon imaging and two-photon optogenetic stimulation both benefit from the latest laser developments targeted squarely at neuroscience research.
    Ip Rgc Stained900px
    Microscopy

    Two-photon imaging helps make discovery about light-sensitive cells in baby's retina

    BioOptics World Editors
    Nov. 27, 2019
    A combination of techniques, including two-photon imaging, found that these light-sensitive cells communicate as part of an interconnected network that gives the retina more light...
    217254 Web
    Neuroscience

    Tapered optical probe helps detect light in the brain

    BioOptics World Editors
    Nov. 19, 2019
    The new method allows the simultaneous collection of signals from various brain regions through the use of a tapered optical probe.
    213584 Web
    Neuroscience

    Optical nanoprobes could have use in monitoring neural activity

    BioOptics World Editors
    Oct. 24, 2019
    The nanoprobes could show how neural circuits function at an unprecedented scale by monitoring large numbers of individual neurons simultaneously.
    0923 Alzheimers 1 Web
    Fluorescence

    Fluorescence monitors how protein aggregate present in Alzheimer's grows

    BioOptics World Editors
    Sept. 30, 2019
    Using a fluorescence method, researchers have found a way to track the formation of soluble amyloid beta peptide aggregates implicated in the onset of Alzheimer's disease.