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    • Highlights

    (Courtesy of Andrey Andreev)
    Fixed-wavelength ultrafast lasers (left) and power supplies (right) are more compact than their tunable Ti:sapphire alternatives (fixed-wavelength laser and power supply are orange; tunable are blue-green). However, for two-photon microscopy, each laser technology has its advantages and disadvantages that the researcher must carefully consider.
    Lasers & Sources

    Two-photon microscopy and the $100,000 question: tunable or fixed-wavelength femtosecond laser?

    Nov. 17, 2020
    Many biologists are unfamiliar with ultrafast laser technology, but still need to decide between tunable or fixed-wavelength lasers for their two-photon microscopy applications...
    Kinetic River Potomac Flow Cytometer
    Biophotonics Techniques

    Kinetic River delivers custom flow cytometer to National Research Council

    BioOptics World Editors
    Nov. 9, 2020
    The customized flow cytometer was installed at the National Research Council in Naples, Italy for biomedical research and water monitoring.
    Trapped Biotin 50538602892 O Cropped
    Biophotonics Techniques

    X-ray crystallography could improve widely used molecular pairing

    BioOptics World Editors
    Oct. 28, 2020
    By creating new ways to control the binding and release of the two molecules, many new lab techniques can now be developed to enable new health discoveries and improved diagnostic...
    FIGURE 1. In SCAPE, a light sheet is formed at an oblique angle by off-axis illumination of the primary microscope objective with a line profile beam (a); SCAPE builds a volumetric image by scanning the light sheet while capturing a series of images of the illuminated plane (b).
    Detectors & Imaging

    High-resolution, multicolor 3D imaging at the speed of life

    Dan Callen
    Oct. 13, 2020
    An innovative laser fluorescence technique, swept confocally aligned planar excitation (SCAPE) microscopy, overcomes the limitations of earlier methods and offers broad life sciences...
    (Courtesy of Madatec Srl, Milan, Italy)
    FIGURE 1. Reflectance spectra of Prussian blue (blue), synthetic lapis lazuli (green), and synthetic azurite (purple).
    Spectroscopy

    Spectroscopy uncovers the hidden in art and archaeology

    Robert V. Chimenti
    Oct. 13, 2020
    Art conservation, cultural heritage, and archaeological studies are key applications for numerous forms of spectroscopy.
    Zeiss
    Detectors & Imaging

    Zeiss fluorescence microscope measures optically cleared specimens up to 2 cm in size

    LFW Staff
    Aug. 28, 2020
    The Lightsheet 7 fluorescence microscope allows fast and gentle imaging of whole living model organisms, tissues, and developing cells.
    Covid 19 4982910 1920
    Biophotonics Techniques

    Multisite COVID-19 patient study uses mass cytometry technology

    BioOptics World Editors
    Aug. 26, 2020
    Mass cytometry technology from Fluidigm is being used in a prospective observational cohort surveillance study of up to 2000 adult participants hospitalized with COVID-19.
    The Organoid Counting Software Analyzes A Single Image In Less Than Three Seconds
    Cell Biology

    CytoSMART Technologies develops automated organoid counter

    BioOptics World Editors
    July 29, 2020
    The automated organoid counter application detects organoids using bright-field image analysis.
    Spectral angle mapping (SAM) allowed differentiation of cells imaged using hyperspectral dark-field microscopy. Cells below the threshold spectral angle are marked as positive using a green outline; cells above the threshold are marked as negative with a red outline. Isolate cell detection shows positive E. coli 157:H7 (a) and Listeria monocytogenes (b). A slide with both pathogens depict E. coli (c) at positive (48) and negative (65), and Listeria monocytogenes (d) at positive (66) and negative (47).
    Detectors & Imaging

    Pathogen detection with hyperspectral dark-field microscopy

    Alexandre Fong
    July 14, 2020
    Aided by deep learning, hyperspectral imaging facilitates high-speed single-cell pathogen detection with no critical volume and little prep.