Fluorescence system correctly identifies residual cancer cells across breast cancer subtypes

Dec. 13, 2017
The system integrates an immuno- and cancer-targeted optical contrast agent, handheld imaging device, and decision software. 

Lumicell (Wellesley, MA) has presented new clinical data from its ongoing Phase 2 breast cancer trial with the LUM System, which integrates the LUM015 immuno- and cancer-targeted optical contrast agent, LUM 2.6 handheld imaging device, and decision software to detect cancer cells in real time during surgery.

Related: Human-safe injectable agent provides fluorescence guidance during cancer surgery

The Phase 2 data demonstrated that the integrated LUM System provided complete and instantaneous detection of residual cancer in tumor cavity and the ability to detect all breast cancer sub-types, including invasive ductal cancer (IDC), invasive lobular cancer (ILC), and ductal carcinoma in situ (DCIS) during lumpectomy surgery. The system also correctly identified residual cancer (positive margins) within the tumor cavity in all patients studied, as confirmed by standard histopathology.

Lumicell's LUM System integrates an immuno- and cancer-targeted optical contrast agent, handheld imaging device, and decision software.

In a poster presentation titled "Real-time, intraoperative detection of residual breast cancer in lumpectomy cavity margins using the LUM Imaging System: Results of a feasibility study," Lumicell collaborators at Massachusetts General Hospital's Breast Program presented data from the Phase 2 clinical study in which tumor cavity walls of patients (N = 45) undergoing breast cancer lumpectomy were assessed intraoperatively using the LUM System. LUM015, a cathepsin-activatable fluorescent agent, was administered intravenously approximately four hours prior to surgery. Areas of fluorescence generated at potential sites of residual tumor in lumpectomy cavities were evaluated with a sterile handheld device, displayed on a monitor, excised and correlated with histopathology. The data showed:

  • The LUM System showed 100% sensitivity and 73% specificity for detection of tumor ≤2 mm from the margin;
  • Invasive ductal, invasive lobular, and areas of ductal carcinoma in situ as small as 1 mm in size were identified using the LUM System; and
  • There were no serious adverse events reported during the study.

The Phase 2 data were presented at the 2017 San Antonio Breast Cancer Symposium (SABCS), held December 5-9, 2017 in San Antonio, TX.

For more information, please visit www.lumicell.com.

About the Author

BioOptics World Editors

We edited the content of this article, which was contributed by outside sources, to fit our style and substance requirements. (Editor’s Note: BioOptics World has folded as a brand and is now part of Laser Focus World, effective in 2022.)

Sponsored Recommendations

Demonstrating Flexible, Powerful 5-axis Laser Micromachining

Sept. 18, 2024
Five-axis scan heads offer fast and flexible solutions for generating precise holes, contoured slots and other geometries with fully defined cross sections. With a suitable system...

Enhance Your Experiments with Chroma's Spectra Viewer

Sept. 5, 2024
Visualize and compare fluorescence spectra with our interactive Spectra Viewer tool. Easily compare and optimize filters and fluorochromes for your experiments with this intuitive...

Optical Filter Orientation Guide

Sept. 5, 2024
Ensure optimal performance of your optical filters with our Orientation Guide. Learn the correct placement and handling techniques to maximize light transmission and filter efficiency...

Ensure Optimal Performance with Shortpass Filters

Sept. 5, 2024
Achieve precise wavelength blocking with our Shortpass Filters. Ideal for applications requiring effective light transmission and cutoff, these filters ensure optimal performance...

Voice your opinion!

To join the conversation, and become an exclusive member of Laser Focus World, create an account today!