Leica Microsystems' (Wetzlar, Germany) OptiGrid module, controlled by Leica MM AF software, integrates with Leica upright and inverted research microscopes and a wide selection of fluorescence cameras. An aperture diaphragm integrated with the fluorescence light path is said to enhance contrast. OptiGrid's automatic focus function keeps the grid structure in focus, from UV to IR light, with no need to change the grid, as one optimized grid covers all magnifications from 10 to 100X.