The Thermo Scientific NanoDrop 3300 fluorospectrometer from Thermo Fisher Scientific (Wilmington, DE) enables cancer and biomedical researchers to study DNA methylation events and polyamine-induced DNA G-quadruplex formations by microvolume fluorometry. The fluorospectrometer takes sample sizes as small as 1 µl using a patented, "cuvette-less” sample retention system, with the ability to analyze multiple emission profiles from a single sample. The fluorospectrometer can also run diverse applications, such as multiple fluorophores, Molecular Beacon Probes, FRET and more. UV, blue and white LED excitation covers a broad wavelength range.