Spectral encoding could allow confocal in vivo imaging of human tissue

Sept. 1, 1998
Gary J. Tearney and colleagues at Wellman Laboratories of Photomedicine, Massachusetts General Hospital (Boston, MA), have demonstrated a submicrometer-resolution scanning confocal microscope that could be miniaturized and incorporated into an endoscope. The researchers suggest that, with improvements, the spectrally encoded confocal microscope (SECM) could be implemented for in vivo diagnostic imaging of human internal tissue.

Spectral encoding could allow confocal in vivo imaging of human tissue

Gary J. Tearney and colleagues at Wellman Laboratories of Photomedicine, Massachusetts General Hospital (Boston, MA), have demonstrated a submicrometer-resolution scanning confocal microscope that could be miniaturized and incorporated into an endoscope. The researchers suggest that, with improvements, the spectrally encoded confocal microscope (SECM) could be implemented for in vivo diagnostic imaging of human internal tissue.

The instrument encodes sample remittance as a function of spatial location using a diffractive optical element to illuminate distinct spatial locations on the sample specimen with different wavelengths of light. The wavelength-division-multiplexed information is transmitted along a single-mode fiber and demultiplexed external to the probe by heterodyne Fourier-transform spectroscopy. The light source is a quasi-monochromatic diode producing 47 µW with a center wavelength at 940 nm and a bandwidth of 75 nm. Because this arrangement does not require fast spatial scanning within the probe, the instrument can be miniaturized. And, according to Tearney, decoding the feedback away from the probe may allow the SECM to provide frame rates compatible with in vivo imaging of human tissue, free of motion artifacts, with equipment compact enough to fit into a small-diameter catheter or endoscope.

Sponsored Recommendations

Request a quote: Micro 3D Printed Part or microArch micro-precision 3D printers

April 11, 2024
See the results for yourself! We'll print a benchmark part so that you can assess our quality. Just send us your file and we'll get to work.

Request a free Micro 3D Printed sample part

April 11, 2024
The best way to understand the part quality we can achieve is by seeing it first-hand. Request a free 3D printed high-precision sample part.

How to Tune Servo Systems: The Basics

April 10, 2024
Learn how to tune a servo system using frequency-based tools to meet system specifications by watching our webinar!

Precision Motion Control for Sample Manipulation in Ultra-High Resolution Tomography

April 10, 2024
Learn the critical items that designers and engineers must consider when attempting to achieve reliable ultra-high resolution tomography results here!

Voice your opinion!

To join the conversation, and become an exclusive member of Laser Focus World, create an account today!