Laura Marcu, Ph.D.

Professor of Biomedical Engineering and Neurological Surgery

Laura Marcu, Ph.D., is a Professor of Biomedical Engineering and Neurological Surgery at the University of California, Davis, and her work focuses primarily on research for development of optical techniques for tissue diagnostics. Her laboratory has developed time-resolved fluorescence spectroscopy (TRFS) and fluorescence lifetime imaging microscopy (FLIM) systems for in vivo tissue interrogation, including human patients. Her laboratory has a broad expertise in clinical translation of biophotonic technologies that play an important role in addressing challenges associate with tissue diagnostics and therapies.

Currently, Dr. Marcu holds a joint appointment as a Professor of Neurological Surgery in the School of Medicine. She serves as Co-leader of the Comprehensive Cancer Center Biomedical Technology Program, Domain Leader of the University of California Center for Accelerated Innovation, and Chair of the Designated Emphasis in Biophotonics and Bioimaging graduate program. She is a fellow of OSA, SPIE, the Biomedical Engineering Society (BMES), and the American Institute of Biomedical Engineering.

(Adapted from Reference 6)
FIGURE 1. The ms-TRFS experimental configuration includes optical pass-band filters with center wavelength/bandwidth: 390/40, 452/45, 542/50, 629/53 nm, respectively (F1 to F4). BS1 to BS4 are dichroic beamsplitters with greater than 93% transmittance for wavelengths longer than 360, 420, 510, and 590 nm, respectively. The system also includes a wavelength selection module, multimode fiber-optic delay lines, and fluorescence detection components. All elements of the fiber selection module are mounted on a compact, 36 × 165 mm breadboard. A FLIm image results from an x-y scan.

FLUORESCENCE SPECTROSCOPY/BIOMEDICAL IMAGING: Fluorescence 'lifetime' moves toward clinical application

July 29, 2014
Time-resolved ("lifetime") fluorescence spectroscopy and imaging provide label-free optical molecular contrast of diseased tissues and outperform steady-state fluorescence. Now...