Wolfgang Drexler

Center for Medical Physics and Biomedical Engineering
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Wolfgang Drexler is the Director of the Center for Medical Physics and Biomedical Engineering, Medical University Vienna (Austria). He earned his PhD in 1995 at the University of Vienna, where he continued as an Assistant Professor until 2000. From 2000 to 2006, he was Associate Professor of Medical Physics at the Center for Biomedical Engineering and Physics at the Medical University of Vienna. In 2001, he received the prestigious Austrian START Award from the Austrian Science Fund. In 2002 he became Director of the Christian Doppler Laboratory for Laser Development and their Application in Medicine. In 2006, he moved to Great Britain, where he was appointed Full Professor of Biomedical Imaging at Cardiff University in Wales.
As a postdoctoral fellow at the Massachusetts Institute of Technology working with with Prof. James G. Fujimoto, he devised and built the first ultrahigh-resolution optical coherence tomography unit. He produced the highest resolution images ever obtained up to that time (1 μm axially), in addition to demonstrating spectroscopy, Doppler imaging, and oximetry with this device. He published this work as the first author of a landmark paper in Nature Medicine in 2001.

FIGURE 1. Foveal portion of corresponding semithin histological section (A) and in vitro OCT image (B) of a perfusion fixed monkey retina(gc ax: ganglion cell axon layer, gc: ganglion cells, ipl: inner plexiform layer, inl: inner nuclear layer, Hf: fibers of Henle, onl: Outer nuclear layer, cis/cos: cone inner/outer segments, pe: Pigment epithelial layer, ch cap: choriocapillaris, ch: choroid, asterisk: darker faults in foveal floor indicative of foveal strain, d: epi-retinal debris). In vivo optical biopsy using ultrahigh resolution ophthalmic OCT of a patient with macular hole (D) compared with histology (C) of a different post mortem eye with comparable stage of macular hole. (Histology (C) provided by R. Brancato, Italy). Endoscopic ultra-high-resolution OCT tomogram (E, F) versus stained histological cross-section (C) of in vivo mouse colon with distally integrated beamsplitter enables visualization of colonic mucosa (CM), muscular mucosa (MM), submucosa (SM), muscularis externa (ME), and serosa (S) layers. Contrast enhanced portion, using local histogram equalization shows a surface layer of apical crypt cells (AC) as well as vertical structures in the mucosa that may correspond to crypt boundaries (C).
Optical Coherence Tomography

OCT imaging leaps to the next generation

Jan. 1, 2008
Noninvasive, simultaneous probing of 3-D cellular-resolution tissue morphology and depth-resolved function could significantly improve early medical diagnosis.