Dr. Christian Eggeling

Fluorescence Correlation Spectroscopy at the nanoscale: Revealing more details with STED microscopy.

SCIENTIFIC CAREER

1990–1992Study of Physics, University of Hamburg, Germany

1992-1996Study of Physics, Georg-August University Göttingen, Germany

1995-1996Diploma work at the Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany, group Dr. C. Seidel, director Prof. J. Troe, Topic: “Photostabilities of dyes for single-molecule fluorescence detection”

1995Research in the group of Prof. R. Rigler at the Karolinska-Institute in Stockholm, Sweden

1996-2000PhD theses Georg-August University Göttingen, Germany, Topic: “Analysis of photochemical kinetic and molecular dynamic through multi-dimensional single-molecule fluorescence spectroscopy”, realized at the Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany, group Dr. C. Seidel, director Prof. J. Troe, rewarded Otto-Hahn Medal of the Max-Planck-Society

2000-2003Scientist at the company Evotec OAI AG Hamburg, Germany: Development of novel (single-molecule based) fluorescence microscopy techniques for high-throughput drug screening

2003-Scientist at the department NanoBiophotonics, Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany, department Prof. Hell

2011Nernst-Haber-Bodenstein price of the German Bunsen Society

SELECTED PUBLICATIONS

1.C. Eggeling, J. F. Fries, L. Brand, R. Günther, C. A. M. Seidel: Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy, Proc. Nat. Acad. Sci. USA 103, 11440-11445, 2006.

2.J. J. Sieber, K. I. Willig, C. Kutzner, C. Gerding-Reimers, B. Harke, G. Donnert, B. Rammner, C. Eggeling, S. W. Hell, H. Grubmuller, T. Lang: Anatomy and dynamics of a supramolecular membrane protein cluster, Science 317, 1072-107, 20

3.G. Donnert, C. Eggeling, S. W. Hell: Major signal increase in fluorescence microscopy through dark-state relaxation, Nat. Methods4, 81-86, 2007.

4.C. Eggeling, C. Ringemann, R. Medda, G. Schwarzmann, K. Sandhoff, S. Polyakova, V. N. Belov, B. Hein, C. von Middendorff, A. Schonle, S. W. Hell: Direct observation of the nanoscale dynamics of membrane lipids in a living cellNature457, 1159-U121, 2009.

5.C. Ringemann, B. Harke, C. von Middendorff, R. Medda, A. Honigmann, R.Wagner, M. Leutenegger, A. Schoenle, S. W. Hell, C. Eggeling: Exploring single-molecule dynamics with fluorescence nanoscopy, New J. Phys.11, 103054, 2009.