FTIR spectroscopy enables prediction of tumor histopathology

April 1, 2008
At Pittcon 2008 (Mar. 2–7; New Orleans, LA), Rohit Bhargava from the University of Illinois (Urbana-Champaign) discussed his group’s work with Fourier-transform infrared (FTIR) spectroscopic imaging to automate the analysis and recognition of tissue structure and disease without the need for dyes, molecular probes, or human intervention.

At Pittcon 2008 (Mar. 2–7; New Orleans, LA), Rohit Bhargava from the University of Illinois (Urbana-Champaign) discussed his group’s work with Fourier-transform infrared (FTIR) spectroscopic imaging to automate the analysis and recognition of tissue structure and disease without the need for dyes, molecular probes, or human intervention. According to Bhargava, FTIR imaging is emerging as a preferred technique for high-throughput biomedical sampling applications, combining the molecular selectivity of spectroscopy with the spatial specificity of optical microscopy.

Working closely with researchers from the National Institutes of Health (Bethesda, MD), Bhargava and colleagues are developing a high-fidelity spectrometer that combines a focal-plane-array detector with a conventional interferometer to potentially increase the speed of data acquisition several-fold. He says they have achieved mathematical noise reduction that enables an approximately 50- to 100-fold higher rate of data collection and have also used optical modeling to elucidate and resolve various confounding optical effects. The team’s technique has been used to automate human cancer diagnoses and grading for different tissue types by applying it to routine archival tissue samples. According to Bhargava, well-defined tests of statistical significance can provide insight into the conditions required to enable the prediction of patient and disease outcomes.

Sponsored Recommendations

Request a quote: Micro 3D Printed Part or microArch micro-precision 3D printers

April 11, 2024
See the results for yourself! We'll print a benchmark part so that you can assess our quality. Just send us your file and we'll get to work.

Request a free Micro 3D Printed sample part

April 11, 2024
The best way to understand the part quality we can achieve is by seeing it first-hand. Request a free 3D printed high-precision sample part.

How to Tune Servo Systems: The Basics

April 10, 2024
Learn how to tune a servo system using frequency-based tools to meet system specifications by watching our webinar!

Precision Motion Control for Sample Manipulation in Ultra-High Resolution Tomography

April 10, 2024
Learn the critical items that designers and engineers must consider when attempting to achieve reliable ultra-high resolution tomography results here!

Voice your opinion!

To join the conversation, and become an exclusive member of Laser Focus World, create an account today!