Nanoparticle tracking analysis characterizes self-assembled nanomotors

Salisbury, England--Nanoparticle tracking analysis from NanoSight, manufacturer of nanoparticle characterization technology, is being used for the characterization of self-assembled nanomotors by Radboud University Nijmegen (Nijmegen, The Netherlands). Jet-engined nanosized rockets may provide a solution for delivering drug packages in the human body, based on the work of Daniela A. Wilson, Roeland J. M. Nolte, and Jan C. M. van Hest from the Institute for Molecules and Materials (IMM) at Radboud University Nijmegen published in Nature Chemistry.

Daniela A. Wilson explains, "Making a nanomotor has been a dream of many researchers in nanotechnology. From molecular machines to micron size self-propelling rods, our team has used a combination of bottom-up or top-down approaches taking years off synthetic work. We applied self-assembly as a tool just like the pieces of a puzzle. The only difference is that we allowed the building blocks make itself to form 350 nm sized motors. The next step was to prove the concept. Having constructed these sub-micron sized nanomotors, we could not use conventional microscopies to visualize them. For 350 nm size particles, we required a special technique and this is how we have come to be users of the NanoSight technique of nanoparticle tracking analysis, NTA. This tracks the motors one by one [in effect, particle-by-particle]. We could even analyze their movement after the addition of their fuel [hydrogen peroxide]."

Wilson continued, "Knowing the particle size was very important to establish the size distribution of our self-assembled nanomotors as well the entrapment of the catalytic particles inside the bowl shape structures. However, even more important for us was the ability to track the movement of the motors in the presence of the fuel. This provided the definitive proof of directed motion resulting from the fast discharge of oxygen."

Prior to using NTA, the IMM group used dynamic light scattering (DLS), which did not provide the ability to track individual particles that was essential for this research. Furthermore, it was vital to be able to analyze particle movement in real time. NanoSight uses tracking and scattering information to provide the size of the particles as well as giving information about the purity of its components. Different refractive indexes materials within the same colloidal distribution will give different scattering and therefore the group is able to use that information to assess the purity and distribution of complex mixtures.

NanoSight says its "Nanoparticle Tracking Analysis" (NTA) detects and visualizes populations of nanoparticles in liquids down to 10 nm, dependent on material, and measures the size of each particle from direct observations of diffusion. Additionally, NanoSight measures concentration and a fluorescence mode differentiates suitably labeled particles within complex background suspensions. Zeta potential measurements assess the surface charge on particles.

SOURCE: NanoSight;

IMAGE: Daniela Wilson with her NanoSight nanoparticle tracking systems at the Radboud University in the Netherlands. (Courtesy NanoSight)

Daniela Wilson with her NanoSight nanoparticle tracking systems at the Radboud University in the Netherlands

Most Popular Articles


Laser Measurements Critical to Successful Additive Manufacturing Processes

Maximizing the stability of the variables going into any manufacturing process is what ensures ts consistency and high quality. Specifically, when a laser is...

Handheld Spectrometers

Spectroscopy is a powerful and versatile tool that traditionally often required a large and bulky instrument. The combination of compact optics and modern pa...
White Papers

Miniature Spectrometers for Narrowband Laser Characterization

In less than 60 years, lasers have transformed from the imagined “ray gun” of science fiction int...

Moxtek ICE Cube™ polarizing beamsplitter

The Moxtek ICE CubeTM polarizing beamsplitter (PBS) product performance is compared to a MacNeill...

Simultaneous Intensity Profiling of Multiple Laser Beams Using the BladeCam-XHR Camera

Measurement of multiple laser beams can be a time-consuming process. However, parallel processing...
Technical Digests

REMOTE FIBER-OPTIC SENSING: Data in abundance from difficult environments

The use of optical fibers to measure strain, temperature, and other parameters at desired points ...

SCANNERS FOR MATERIALS PROCESSING: Serving demanding applications

Galvanometer-based scanners are an essential component in laser-based materials-processing system...

OPTICAL COATINGS: Evolving technology produces new benefits

The antireflection, high-reflection, and/or spectral characteristics provided by optical coatings...

FREEFORM OPTICS: Top-notch capabilities lead to expanded possibilities

The use of free-form aspherical surfaces in an optical system can give it abilities impossible to...

Click here to have your products listed in the Laser Focus World Buyers Guide.


Bristol Instruments Introduces Laser Spectrum Analyzer

09/07/2011 Bristol Instruments Introduces Laser Spectrum Analyzer for Infrared Lasers Complete wavelength an...

New Optical Wavelength Meters

09/07/2011 –Bristol Instruments, Inc., founded by three former employees of Burleigh, has announced the intr...
Social Activity
Copyright © 2007-2015. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS