Cell Imaging/Cell Analysis: EUV-enabled spectrometry images cells in 3D at nanoscale

Feb. 17, 2016
Researchers at Colorado State University (Fort Collins, CO) have developed a spectral imaging instrument that maps cellular composition in 3D at the nanoscale.

Researchers at Colorado State University (Fort Collins, CO) have developed a spectral imaging instrument that maps cellular composition in 3D at the nanoscale.1 The system allows study of cells at approximately 100% greater detail than previously possible, enabling observation of cell response to drugs.

The researchers explain that earlier laser-based mass-spectral imaging could identify the chemical composition of a cell and could map its surface in 2D at the microscale, but could not chart cellular anatomy in nanoscale or in 3D.

The instrument features a laser able to produce a hot, dense plasma stream that acts as a gain medium for generating extreme ultraviolet (EUV) pulses. When properly focused, the laser drills a tiny hole into a cell sample, enabling ions to evaporate from the cell surface. These ions can be separated and identified to determine chemical composition, and used to chart the anatomy of a cell.

1. I. Kuznetsov, NatureCommun., 6, 6944, doi:10.1038/ncomms7944 (2015).

About the Author

Barbara Gefvert | Editor-in-Chief, BioOptics World (2008-2020)

Barbara G. Gefvert has been a science and technology editor and writer since 1987, and served as editor in chief on multiple publications, including Sensors magazine for nearly a decade.

Sponsored Recommendations

How Precision Motion Systems are Shaping the Future of Semiconductor Manufacturing

March 28, 2024
This article highlights the pivotal role precision motion systems play in supporting the latest semiconductor manufacturing trends.

Understanding 3D Printing Tolerances: A Guide to Achieving Precision in Additive Manufacturing

March 28, 2024
In the world of additive manufacturing, precision is paramount. One crucial aspect of ensuring precision in 3D printing is understanding tolerances. In this article, we’ll explore...

Automation Technologies to Scale PIC Testing from Lab to Fab

March 28, 2024
This webinar will cover the basics of precision motion systems for PIC testing and discuss the ways motion solutions can be specifically designed to address the production-scale...

Case Study: Medical Tube Laser Processing

March 28, 2024
To enhance their cardiovascular stent’s precision, optimize throughput and elevate part quality, a renowned manufacturer of medical products embarked on a mission to fabricate...

Voice your opinion!

To join the conversation, and become an exclusive member of Laser Focus World, create an account today!