Fluorescence

March 3, 2024

Lasers & Sources

LED illumination system has use in fluorescence imaging applications

Feb. 6, 2024

Digital microscope camera offers AI-based scene detection

Jan. 31, 2024

CMOS camera images low-light signals for extended time periods

Jan. 13, 2024

FLIM camera system features a SPAD detector

Nov. 27, 2023

Highlights

Spectral detector enables fast spectral FLIM data acquisition

Nov. 9, 2023

The Parallel 16-PMT Spectra FastFLIM is a time-resolved spectral detector with parallel 16-channel digital frequency-domain fluorescence lifetime imaging (FLIM) readouts.

FIGURE 1. An optomechanical design of the SMURF two-photon microscope.

A brain imaging trifecta

July 13, 2023

An approach to imaging electrical activity deep in the brain makes neurological studies more effective and less invasive.

Lasers & Sources

Single-frequency laser offers up to 1 W output power

July 5, 2023

The Cobolt Jive 561 nm continuous-wave (CW) single-frequency diode-pumped laser operates at 561.2 nm.

FIGURE 1. Lumicell’s LUMISIGHT optical imaging agent and direct visualization system assists surgeons in detecting residual cancer after surgery.

Fluorescence imaging system may improve cancer care

June 12, 2023

Currently under review by the U.S. FDA, a handheld imaging probe may help surgeons detect residual cancer after surgery via a contrast agent.

Monochrome camera provides IR and near-IR sensitivity

May 30, 2023

The See3CAM_50CUGM Sony Pregius IMX264 global-shutter monochrome camera includes back-illuminated technology and a 3.45 µm pixel size.

Test & Measurement

Fluorescence analyzers add pulse processing algorithm feature

April 8, 2023

sCMOS camera is suited for life science imaging

Jan. 2, 2023

FIGURE 1. Screenshot of hardware and analysis settings for a smFRET experiment with 532 nm and 640 nm pulsed interleaved excitation and dual-channel detection, yielding three logical analysis channels.

Novel microscope for dynamic structural biology with single-molecule FRET

Maria Loidolt-Krüger

Dec. 16, 2022

FIGURE 1. The new microscope re-distributes light from a volume such that many depths are imaged simultaneously next to each other, allowing a fast camera to record the entire volume in a single shot.

Next-generation microscope boosts opportunities

Dec. 8, 2022

FIGURE 1. A 3-g MINI2P miniaturized head-mounted two-photon microscope.

Two-photon microscopy advances bio research

Joseph Mastron

Dec. 6, 2022

Decades of research focused on two-photon laser scanning microscopy is enabling new ways for neuroscientists to measure in vivo neuronal activity in three dimensions.

FIGURE 1. BaSISS clonal maps trace cancer evolutionary lineages in space.

Understanding cancer’s genetic makeup could halt its spread

Dec. 2, 2022

A molecular microscopy technique is helping researchers more effectively identify cellular DNA and RNA in breast cancer cells. This could lead to development of new treatments...

A schematic of DopaFilm shows spatially resolved hotspots of activity (top) and DopaFilm’s fluorescent nanosensors glow brighter when exposed to dopamine (bottom).

Material made of fluorescent nanosensors may boost neural discoveries

Oct. 26, 2022

By measuring the release of dopamine and other neurotransmitters, a composite material can help provide a better understanding of chemical neurotransmission.

CCD cameras feature deep-depletion design